OT Receptors For the effective formation of immune synapses resulting in T-cell-mediated tumor cell lysis, the scDb/scFv-Fc format with small interdomain spacing in the (1-2)+1?and (2-1)+1 configuration showed efficient killing of medium HER3-expressing cancer cells while sparing target cells with low HER3 expression with an additional preferable safety profile due to low cytokine secretion tuskonus December 29, 2024